A “Link-Psi” strategy using crosslinking indicates that the folding transition state of ubiquitin is not very malleable
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چکیده
منابع مشابه
Transition state heterogeneity in GCN4 coiled coil folding studied by using multisite mutations and crosslinking.
We have investigated the folding behavior of dimeric and covalently crosslinked versions of the 33-residue alpha-helical GCN4-p1 coiled coil derived from the leucine zipper region of the transcriptional activator GCN4. The effects of multisite substitutions indicate that folding occurs along multiple routes with nucleation sites located throughout the protein. The similarity in activation energ...
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ژورنال
عنوان ژورنال: Protein Science
سال: 2012
ISSN: 0961-8368
DOI: 10.1002/pro.2065